Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomicsArticle Published on 2022-12-012022-11-16 Journal: Environmental research [Category] 유전자 메커니즘, [키워드] acute phase analyzed Blood Cohort coronavirus disease COVID-19 COVID-19 patient CpG DNA DNA methylation dose downregulated embryogenesis epidemiological data epigenomic epigenomics Evidence expression female females gene product Genetic variation Genome-wide association studies Host inactivation incidence incidence of COVID-19 independent insight long-COVID-19 male males Methylation n-Counter. nasal patients Post-infection RNAseq Saliva Severe case severe COVID-19 severity Sex significantly higher stratified suggested timepoint TLR7 TLR7 gene transcriptomics with COVID-19 [DOI] 10.1016/j.envres.2022.114288 PMC 바로가기
Durable antibody and effector memory T cell responses in breastmilk from women with SARS-CoV-2Article Published on 2022-09-122022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] antibody asked B.1.1.7 B.1.351 Beta binding Blood breast milk breast permeability breastmilk CCR7 CD4 CD45RO CD8 T cell Cell complex COVID-19 COVID-19 vaccine D614G domain dried blood spot effector memory elect enrolled expressed first COVID-19 symptom flow cytometry Gamma IgA IgA response IgG IgM Immunity Immunoglobulin indicated Infant lactating memory memory T memory T cells milk mother mucosal mucosal immunity. neutralize neutralized Neutralizing P.1 participant passive immunity permeability positive potassium ion pregnant women Protective reactivity receive robust SARS-CoV-2 SARS-COV-2 infection second set significantly higher sodium Stool T cell T cell response tested the spike protein timepoint was collected were assessed women [DOI] 10.3389/fimmu.2022.985226 PMC 바로가기
Novel application of [18F]DPA714 for visualizing the pulmonary inflammation process of SARS-CoV-2-infection in rhesus monkeys (Macaca mulatta)Article Published on 2022-09-012022-11-16 Journal: Nuclear medicine and biology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Activation added BAL Blood Bronchoalveolar lavage Chest COVID-19 dendritic cell determine diagnostic increased expression Infection infection process Inflammation initial injection lesions lung lung tissue Lymph node marker nonhuman primates novel performed pet PET-CT positive post infection principal pulmonary pulmonary inflammation pulmonary lesion pulmonary lesions Rhesus monkey Rhesus monkeys SARS-CoV-2 Seven Swab swabs timepoint TSPO TSPO. viral respiratory infections [DOI] 10.1016/j.nucmedbio.2022.05.002 PMC 바로가기
Acute kidney injury associated to COVID-19 leads to a strong unbalance of circulant immune mediatorsCOVID-19와 관련된 급성 신장 손상은 순환 면역 매개체의 강한 불균형으로 이어집니다Article Published on 2022-09-012022-09-12 Journal: Cytokine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, [키워드] accompanied Acute kidney injury AKI AKI patient AKI patients alteration analyzed association CCL-2 CCL-3 clinical outcomes contribute coronavirus disease COVID-19 COVID-19 patient CXCL-10 CXCL-8 Cytokines death demonstrated diabete Follow-up Frequency hospital discharge hospitalized patient IFN-γ IL-10 IL-2 IL-6 immune Immune mediators. immune response immunoassay immunopathological increased risk investigated kidney Kidney injury male moderate multiplex Patient performed Predictive ROC Curve SARS-CoV-2 viral load severe COVID-19 significantly significantly higher sustained the disease timepoint TNF-α VEGF Viral load were measured [DOI] 10.1016/j.cyto.2022.155974 PMC 바로가기 [Article Type] Article
Antibody-Mediated Immunogenicity Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Following Priming, Boosting, and Hybrid Immunity: Insights From 11 Months of Follow-up of a Healthcare Worker Cohort in Israel, December 2020-October 2021프라이밍, 부스팅 및 하이브리드 면역에 따른 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)에 대한 항체 매개 면역원성: 이스라엘 의료 종사자 집단의 11개월 추적 관찰에서 얻은 통찰력, 2020년 12월-2021년 10월Article Published on 2022-08-242022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, [키워드] acute respiratory syndrome Against age all age group all age groups anti-S Antibody titer Breakthrough infection circulating Cohort comparable coronavirus coronavirus 2 coronavirus disease COVID-19 decrease described dose doses geometric mean concentration GMC HCW HCWs healthcare worker highlight hybrid IgG IgG level IgG levels IgG titer Immunity immunogenicity Immunoglobulin individual infected individual infected individuals Infection initial insight Israel Month participant PCR polymerase chain proportion Protective Quantitative re-infected Reinfection remained respiratory reversed S1/S2 SARS-CoV-2 subsequent tested timepoint uninfected vaccination Vaccine vaccine immunogenicity Vaccines Vaccines. waned worker [DOI] 10.1093/cid/ciac212 PMC 바로가기 [Article Type] Article
T-cell recovery and evidence of persistent immune activation 12 months after severe COVID-19심각한 COVID-19 이후 12개월 동안 T 세포 회복 및 지속적인 면역 활성화의 증거Article Published on 2022-08-012022-09-11 Journal: Allergy [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] accompanied acute infection administration analyzed assays Asymptomatic CD38 CD4 CD8 Characteristics clinical recovery coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine Critical Cytometry dysregulated immune response enrolled Evidence evidence of exhibited exhibiting expression flow cytometry Follow-up functional hallmark HLA-DR immune activation impairment independent independent of individual Infection investigated lymphopenia Mild Most patients normalization Patient persistent phenotype phenotypic Post-infection pro-inflammatory cytokine proteomics recovery. SARS-CoV-2 severe COVID-19 severe COVID-19 patient severe COVID-19 patients subgroup of patient T cell T cells T-cell T-cell activation T-cell Response These cells timepoint viral antigens [DOI] 10.1111/all.15372 PMC 바로가기 [Article Type] Article
Dynamics of antibody titers and cellular immunity among Japanese healthcare workers during the 6 months after receiving two doses of BNT162b2 mRNA vaccineBNT162b2 mRNA 백신 2회 접종 후 6개월 동안 일본 의료 종사자의 항체 역가 및 세포 면역의 역학Article Published on 2022-07-302022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] All participant All participants Analysis antibody Antibody titer Antibody titers Asymptomatic BNT162b2 BNT162b2 mRNA BNT162b2 vaccine Breakthrough infection breakthrough infections Cellular immune response cellular immune responses cellular immunity clinical trial collected conducted COVID-19 determinant determinants determine dose Dynamics elevated follow-up period healthcare healthcare worker Healthcare workers humoral IgG immune response immune responses incidence Japanese knowledge medical condition Medical conditions mRNA vaccine mRNA vaccines mRNA vaccines. Nucleocapsid proteins of BNT162b2 participant Pfizer Pfizer-BioNTech positive prospective cohort study receiving SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine seroconverted serum sample serum samples study period T-cell immune response T-cell immune responses timepoint vaccination Vaccine waned were measured within 6 months [DOI] 10.1016/j.vaccine.2022.06.016 PMC 바로가기 [Article Type] Article
Efficacy and safety of a single dose of casirivimab and imdevimab for the prevention of COVID-19 over an 8-month period: a randomised, double-blind, placebo-controlled trialRandomized Controlled Trial Published on 2022-07-052022-10-05 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 임상, 진단, [키워드] 1:1 active against addition age Analysis assigned B.1.1.529 baseline Community Complete COVID-19 COVID-19 symptom COVID-19 vaccination COVID-19 vaccine death diagnostic dose double-blind drugs Efficacy Endpoint expected finding follow-up period funding Health healthy Hoffmann-La Roche hospitalised household contact immune response incidence infected individuals Infectious diseases investigator Local monoclonal antibody combination mounted occurred participant patient population Placebo placebo-controlled trial post-hoc post-hoc analysis prespecified analysis prevented prevention of COVID-19 Prophylaxis proportion provided randomisation randomised Randomly receive receiving reduced Regeneron Pharmaceuticals Registered reported risk of COVID-19 risk reduction Romania RT-PCR testing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected individual Seroconversion seronegative seropositive shown single dose strain stratified subcutaneous injection susceptible symptomatic SARS-CoV-2 infection the placebo group timepoint treatment-emergent adverse event treatment-emergent adverse events uninfected unmet need USA variants waned [DOI] 10.1016/S1473-3099(22)00416-9 [Article Type] Randomized Controlled Trial
Longitudinal variation in SARS-CoV-2 antibody levels and emergence of viral variants: a serological analysisSARS-CoV-2 항체 수준의 종단적 변이와 바이러스 변이체의 출현: 혈청학적 분석Article Published on 2022-07-012022-09-11 Journal: The Lancet. Microbe [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료법, [키워드] absence analysis antibody antibody levels Antibody Response Antibody responses Antibody titre assays baseline Clinical practice Cohort correlation correlation analyses COVID-19 vaccine declined detectable Deterioration determine determined by Effect facilitate functional Immunity individual Infection longitudinal MONITOR National Health Service neutralisation activity neutralisation assays neutralising Neutralising activity neutralising antibody titre neutralising antibody titres nucleocapsid participants with SARS-CoV-2 Post-infection predict Predictive Predictive value presence or absence SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection sensitivities sensitivity serological analysis Serological assay serological assays serological measurement serological measurements serological test Serological tests serum sample serum samples Spearman Spike protein Spike protein sequence subsequent Surrogates the spike protein These data threshold timepoint timepoints titres two-tailed variants variants of concern Variation Viral viral variant Viral variants [DOI] 10.1016/S2666-5247(22)00090-8 PMC 바로가기 [Article Type] Article
Cross-sectional survey of changes in knowledge, attitudes and practice of mask use in Sydney and Melbourne during the 2020 COVID-19 pandemicObservational Study Published on 2022-06-222022-10-04 Journal: BMJ Open [Category] COVID19(2023년), SARS, 임상, [키워드] 2020 COVID-19 pandemic 95% CI changes in Cluster Compliance COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 severity cross-sectional survey decrease Epidemiology explained Government Infection information knowledge mask mandate Mask mandates Measures Melbourne Melbourne, Australia National no significant difference Older outbreak pandemic participant Perceived Personal protective equipment public health public health. reported risk risk of COVID-19 risk perceptions second wave secondary outcome setting severity significantly susceptibility the timing timepoint Trust Victoria [DOI] 10.1136/bmjopen-2021-057860 PMC 바로가기 [Article Type] Observational Study